As mentioned above, the Airmatic might sink down after not being used for a few weeks but it shouldn't give you any problems.
Same happens in my Audi - over time the car's systems will gradually shut down one by one if not used and after 10 days or so the air suspension sinks right down over the arches, almost to the floor. So I imagine it will be similar in the W221.
I'd leave the parking brake off if the ground is flat. Or just chock the wheels if on a slight slope.
If it was me then I'd take no measures and just leave it how it is and not worry