Yes, I have used it for a while on a Samsung NC10 Netbook, dual-booting alongside the standard XP.
Clean-installed the RC yesterday having been part of the Beta program earlier. Impressed with the quick setup and the included drivers - almost zero work to do after the standard "install then let windows update run" cycle.
Seems to be about as quick as XP and so far no problems. Using Kaspersky for anti-virus and Firefox browsing.
Also using the netbook to "remote desktop" into the i7 Vista desktop PC where my files live.