Yes W1ghty, and that's how I did the last change on my 722.6 trans..technically ( and realistically) disconnect one of the two cooler pipes (my choice is the drivers side one) attach a drain pipe to it. Then fit a large funnel into the dipstick / refill pipe. Run engine with the drive in "P" and pump out 2 litres into the container, repeat until the new fluid appears. Job done, as far as all of the oil has been changed, But the sump will have to come down to change the filter and no way around that whatever method used., even when its machine chaned, better at the beginning of the job, IMHO.
OneForThe Road. If you look up MB Bevo list, you will see what ATF you will need for your trans,,,,,and they will also list all the MB approved trans fluid manufacturers, so you can take your pick. I've got 20 Ltrs of Fuchs Titan ATF 7134 FE for the next change in my 220 E class 722.9 trans,