I really cannot see why not. I've owned A's, B's, C's, E's, two ML's and an S class and every one of them has delivered the combined figure on a reasonable run, cruising at the legal max. My current ML gives just over the 32 mpg combined figure on a run with little effort on my part.
All the cars I have owned have also had reviews in the press achieving the combined figure on a run driven 'sensibly' and numerous threads from other owners getting at least the combined figure on a run.
My E220cdi estate had a claimed combined figure of 38.6 mpg and I regularly got into the forties on a run. My S320cdi had a claimed combined figure of 35 and that yielded 37 mpg on a trip to the South of France and back. And more on some other trips in the UK. Other owners reported getting far more.
