Comment below refers to M272 M/Y 2009. This and later engines should have had most problems solved.
The M272 V6 Petrol has a double linked timing chain. This type of chain should not wear out like the single-linked ones in the 4-cylinder in-lines.
The problems with the M272 and M273 was caused by sintered gears used for the timing chain and balancing shafts in the V6 and the timing chain in the V8
The sintered gears was replaced with solid ones following specific engine serial numbers that can be found on the internet.
Apart from gear issues, there has been some other problems reported with the variable timing control sensors. There are some 70+
sensors and control functions on an M272 engine.
After 100,000 kms there is a risk of cracked crank case ventillation hose(s) that throws DTC's. Not too logical fault to find as the
crack manifests itself in a similar way as a bad air-mass meter or faulty lambda sonds. The crack int the hose appears on the metal side
of the engine (facing down). The hose will have to be lifted up for the crack to be seen.
I owned a C207 with the 3.5 litre petrol V6. Someone here wrote that it is the "sweet spot" and in the C207 it did the job exceptionally well.
But it is a thirsty engine. It takes some time before it reaches the optimum operating temperature during which it is a gas guzzler.
On the long haul driving at legal speeds on highways it consumes anout 7.5 litre/100 km.
The M272 Petrol CGI/SFI version exhaust system has 4 lambda sensors and several NOx-sensors and thermistors. Mercedes have had problems like many
others with NOx sensor quality and they are expenceive to replace. Apart from the component cost, they will have to be configured in the vehicle
with the Xentry system.
And as with any second hand car that old, always have an extra couple of thousand bucks for those unexpected "Check-Engine" that lights up when you want it the least...