If the suspension is designed/tuned to use wheels shod with run-flats going to 'normal' tyres might be detrimental to the ride and handling?
Tyres are an integral part of the suspension system and effectively what you have is two springs in series. When you have two springs in series the resulting overall rate is always lower than either of the individual springs. While it's possible that it is detrimental to both ride and handling it's more likely to just move the bias in the direction of improved low speed ride. While normal tyres undoubtable did that to a very noticeable extent on the early BMW's with run flats it should still do so on the better tuned more recent models, even if it's a less obvious improvement.
If we knew the relative spring rates of normal tyres vs run flats it would be possible to calculate the impact on overall spring rate. For two springs in series the overall spring rate is:
(Spring 1 times Spring 2) divided by ( Spring 1 + Spring 2)