Has the car been Valet parked, or left to be carwashed (and open) in the last few weeks ?
I ask because if someone was breaking in to steal this, I think they would immediately start by pulling up the gear lever surround, rather than trying to lever it out - unless they knew it was not screwed in.
Or as some other poster says, I wonder it it is possible to access the screws above with the CDC compartment open - I have never checked, but anyone else with a W211 may like to shine a torch upwards and see if they can see some screws going into the bottom of the comand (well, they slide those metal bars in the picture) ..
Also, was the Navigation drive from the boot taken too ? If you look on eBay most sales of units are head unit + navigation drive, so it seems strange someone would break in and not take that if they had just picked any old E class with COMAND.
Richard