The W220 from '99 (MY'00) through MY '02 has the COMAND 2.5, narrow-screen CD-based, D2B fiber optics unit. To complicate it more, the early MY '00 (until November '99) were produced with "C" nav units, which used discs not compatible with the later "D" nav. The "C" nav CDs are no longer in production. The "D" nav CDs are still being updated. Changing out a "C" nav for a "D" nav is plug 'n play.
To answer the questions that usually follow this discussion, the latest (2009) update for the "D" nav is BQ 6 46 0248 at the time of this writing. The latest "C" nav set is 02/04 and the part number is BQ 6 46 019.
http://forums.mbworld.org/forums/s-c...257-d-nav.html provides an easy way to tell which system you have.
The '03 model year introduced a wide-screen CD based COMAND, called COMAND MOPF. It also took the Audio Gateway (AGW) out of the COMAND unit itself, and made it separate. The COMAND MOPF is a D2B based system that also uses the "D" nav unit, and the same discs as the late '00 through '02.
The wide screen COMAND MOPF can be retrofitted to earlier cars, but you must also add the AGW, so it is not plug and play - but it can be done.
In MY '04 MB went to the MOST fiber optic bus, and a DVD-based nav system, the wide screen COMAND 2.0. D2B and MOST systems are not compatible. To change from D2B to MOST would require replacing all of the D2B fiber optics - the harnesses and everything on the bus (COMAND, amp, phone, voice control, nav, CDC - you name it). I know of one person who has done it in at least two cars (Sunilp on the forums), but it's about a $10,000 or better proposition. You're better off buying a newer car.
So as a practical matter you cannot go from the '03 widescreen COMAND MOPF to the widescreen DVD COMAND 2.0. You'd be trying to fit a MOST system to a D2B bus.
