I had 18's on a previous S320. I was running 34 on the front and 36 on the back.
Hint of advice with 18 inch tyres is to check the pressure every few weeks and top up as required.
I have 225 45 17's on a C220D 1996 and I called tech services at Firestone and Toyo and they both stated to use original tyre pressures as details on fuel filler cap or a couple of psi higher max - not what I was expecting to hear, thought a lot higher, but still.