I've just picked up a CLS W219 on an 06 plate.
The keyless start works fine and the keyless entry on the boot works but not the doors. Can anyone offer me some advice?
If you have tested *all four* door handles and none of them work on either lock or unlock then you either have four faulty handles OR another issue completely.
You can remove one of the handles and test it with a multimeter.
They are common to fail but it's unusual to have all four faulty on both lock and unlock functions.