Do you mean as in an aftermarket double din unit that will fit?
If so, we replaced our Comand with an Alpine INE-W947E. 7" screen, Navigation all the bells and whistles including the reversing camera if you want one.
Although, as I found out on this forum, the Comand controls the clock time setting so that will need to be changed.
You could select a decent Alpine or Kenwood as an alternative to the Comand but before you do, make sure you can get a fascia adapter for your particular model and if you have BOse you will need an amplifier too.