Using basic theory from bike engines and expanding it:
A straight 6 is a balanced engine. One cylinder fires every 120 degress, 120*6=720. Straightforward and balanced, and all of the pistons are doing the same movement reciprocated by another piston.
As for V engines, a 90 degree vee has perfect primary balance, a 60, or 45, or 72 etc, does not. This is why harleys with their narrow angle V engines (45 degrees I think) and no balance shafts vibrate a lot.
So you add a balance shaft to a V6, and it becomes smooth. However a balance shaft is weight, its a bit like adding a heavier flywheel. So if the engine has the same bore and stroke as the straigh 6, it will make a little less power but slightly better torque from the higher rotating mass.
I would also expect it to be slightly less effiecient - the engine has an extra shaft to turn. The Vee is a more modern engine than the straight though, so you can expect better tolerances there.
Of course, the straight 6 is also more vulnerable to the twisting forces along the length of its crankshaft, the chance of warping one of those long camshafts, and the simple fact that the merc head gaskets on the straight sixes always tended to start weeping oil after a few years and miles.