SPEC/PART NUMBER FRONT 8.5J X 19 EH2 ET30 A211400 1202 A171400 0302 WITH 255/35/19 96Y REAR 9.5J X 19 EH2 ET31 A2114001402 A1714000402 WITH 285/30/ZR19 98Y.....Does this answer? sorry for ignorance and thanks for your help.
You have the link to the fitting chart above, just compare. If the ET of the wheels is higher than you need you can use spacers to fit them. If the ET of the wheels is already lower than you need then no they wont fit (unless the ET is only different by a couple of mm).
Yes, 19" wheels will fit the W221 S Class. However based upon the details and part no's posted by the original poster, the specific wheels he had in mind wouldn't.
As mentioned by Bill, the offset (ET) is very important.