Alfie's firm retrofitted COMAND to my car.... he knows everything there is to know about these things, so if he says it won't work, then it won't work.
From what I understand, the pre-facelift W212 was originally fitted with NTG4. This means that you should be able to retrofit COMAND NTG4 from another pre-facelift W212 (2010-2013), replacing your Audio20.
(I don't know when MB started using anti-theft protection, so not sure if NTG4 can be transferred to another car or not)
That said, NTG4 is an outdated system in today's standards, so you might want to consider an after-market Android unit instead, e.g.:
(I am not recommending this particular brand, this is just an example).
Personally, I decided that I preferred the original feel and look of COMAND, so had that retrofitting, but I am aware that there are those who prefer the Android unit.
(One advantage of the non-MB unit for DIYers, is that it does not require coding, so no need for STAR).