I've just sold my 2002, S210, 320CDI to a fellow member.
At 151,000 miles, I don't think it is quite run in yet.
I've over-spent on bringing the car up to my standards, but I know it will continue to give pleasing performance for many a year to come. Every time I had to travel 4-500 miles in a day, I actually looked forward to the experience.
It's a great car to travel in, and considering its size, weight and load-lugging capabilities, it really does thunder along and the MPG level is very good. That engine will still be ticking over when they bury it one day.
IIRC there are some taxi's that have clocked up in excess of 600,000 miles with the same OM613 engine.
I'll miss the E-Class, (the sole reason for selling it is that I never really get chance to use it these days) but I have the option to buy it back one day, which is why I wanted it to go to a MB Club member who I know will look after it.