Over the last two decades, I've had 2 S500's (W220 & W221), 4 E500's (211 and 212) and an E55.
My personal favourites, by a country mile were the S500L's for their leading edge tech, comfort, luxury and, power and ride quality.
But....my wife loathes the length of the S500L. She's tiny and loves her Mx5.
But 2....I always run older cars, a decade old. So I'm deliberately avoiding the tear-jerking depreciation of a less than six year old S class.
Reliability? Can't comment. I haven't had any repairs in maybe 150,000 miles, apart from an electric handbrake on the W221 which was jammed off when I bought it.
I can fit an S500L into my garage, which is nice, and I don't have to parallel park on London roads very often.
Have had "difficult situations" when trying to park these things in Paris and Monaco. French multi-storeys aren't made for cars this big. But they're just as bad for big SUV's
On the other hand, I did take a ride in a friend's brand new S500 this Christmas and I hated the Ipaddery of that central console. But then I hate most such displays - from Tesla S to EQS.
The only way to judge it is to just drive one yourself.