FWIW, here's my experiences. I fitted a good quality tuning box to my old S210 when I had it. It worked well and gave bags more power and torque. However, it didn't seem to do anything for the economy and the car always left a huge cloud of black smoke behind if I floored it. The box didn't stay fitted for long!
I had my last S211 remapped - wonderful increase in power - did nothing for throttle/turbo/gearbox lag - did nothing for economy - made more smoke than it should and wouldn't get through the MOT, so the mapping was reverted to standard very quickly!
I have no doubt that some remaps can work well, but I'm of the opinion that it needs to be custom mapping rather than anything generic if problems are to be avoided. However, the exception to this seems to be the Brabus boxes, which are reputed to work well.